Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Varanus salvator
water monitor - (species) D
Varanus niloticus
(species) D
Varanus albigularis
cape monitor - (species) D
Interspecific
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000699
Atp1a1
Q8VDN2
Physiology
2 mutations
Varanus tristis
(species)
Varanus mitchelli
(species)
Varanus scalaris
(species)
Varanus salvator
water monitor - (species) D
Varanus niloticus
(species) D
Varanus albigularis
cape monitor - (species) D
Na/K-ATPase alpha-subunit
Varanus salvator
water monitor - (species)
Varanus niloticus
(species)
Varanus albigularis
cape monitor - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Natricinae
(subfamily) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000700
Atp1a1
Q8VDN2
Physiology
2 mutations
Colubridae
colubrid snakes - (family)
Natricinae
(subfamily) D
Na/K-ATPase alpha-subunit
Natricinae
(subfamily)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Leptodactylus ocellatus
argus frog - (species) D
Intraspecific
Candidate Gene
Moore DJ; Halliday DC; Rowell DM ; et al. (2009)
Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...]
1 Additional References
GP00000701
Atp1a1
Q8VDN2
Physiology
2 mutations
Leptodactylus ocellatus
argus frog - (species)
Leptodactylus ocellatus
argus frog - (species) D
Na/K-ATPase alpha-subunit
Leptodactylus ocellatus
argus frog - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Atelopus spumarius
Pebas stubfoot toad - (species) D
Rhinella marina
marine toad - (species) D
Rhinella granulosa
granular toad - (species) D
Intergeneric or Higher
Candidate Gene
Moore DJ; Halliday DC; Rowell DM ; et al. (2009)
Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...]
1 Additional References
GP00000702
Atp1a1
Q8VDN2
Physiology
2 mutations
Hyloidea
(superfamily)
Atelopus spumarius
Pebas stubfoot toad - (species) D
Rhinella marina
marine toad - (species) D
Rhinella granulosa
granular toad - (species) D
Na/K-ATPase alpha-subunit
Atelopus spumarius
Pebas stubfoot toad - (species)
Rhinella marina
marine toad - (species)
Rhinella granulosa
granular toad - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Naja melanoleuca
forest cobra - (species) D
Naja naja
Indian cobra - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000703
Atp1a1
Q8VDN2
Physiology
2 mutations
Ophiophagus hannah
king cobra - (species)
Pseudechis australis
mulga snake - (species)
Hemiaspis signata
(species)
Naja melanoleuca
forest cobra - (species) D
Naja naja
Indian cobra - (species) D
Na/K-ATPase alpha-subunit
Naja melanoleuca
forest cobra - (species)
Naja naja
Indian cobra - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
4 Mutations:
Coding
SNP
Chrysochus auratus
dogbane beetle - (species) D
Interspecific
Candidate Gene
Aardema ML; Zhen Y; Andolfatto P (2012)
The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies.
1 Additional References
GP00000704
Atp1a1
Q8VDN2
Physiology
4 mutations
Coleoptera
beetles - (order)
Chrysochus auratus
dogbane beetle - (species) D
Na/K-ATPase alpha-subunit
Chrysochus auratus
dogbane beetle - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Rhyssomatus lineaticollis
(species) D
Interspecific
Candidate Gene
Zhen Y; Aardema ML; Medina EM ; et al. (2012)
Parallel molecular evolution in an herbivore community.
GP00000705
K+ ATPase alpha subunit
R4ZHW8
Physiology
C104Y
Coleoptera
beetles - (order)
Rhyssomatus lineaticollis
(species) D
Na/K-ATPase alpha-subunit
Rhyssomatus lineaticollis
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Tetraopes tetrophthalmus
red milkweed beetle - (species) D
Interspecific
Candidate Gene
Zhen Y; Aardema ML; Medina EM ; et al. (2012)
Parallel molecular evolution in an herbivore community.
1 Additional References
GP00000706
Atp1a1
Q8VDN2
Physiology
2 mutations
Coleoptera
beetles - (order)
Tetraopes tetrophthalmus
red milkweed beetle - (species) D
Na/K-ATPase alpha-subunit
Tetraopes tetrophthalmus
red milkweed beetle - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Erinaceus europaeus
western European hedgehog - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000708
Atp1a1
Q8VDN2
Physiology
2 mutations
Condylura cristata
star-nosed mole - (species)
Erinaceus europaeus
western European hedgehog - (species) D
Na/K-ATPase alpha-subunit
Erinaceus europaeus
western European hedgehog - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
4 Mutations:
Coding
SNP
Oncopeltus fasciatus
milkweed bug - (species) D
Lygaeus kalmii
(species) D
Intergeneric or Higher
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
2 Additional References
GP00000709
Atp1a1
Q8VDN2
Physiology
4 mutations
Insecta
true insects - (class)
Oncopeltus fasciatus
milkweed bug - (species) D
Lygaeus kalmii
(species) D
Na/K-ATPase alpha-subunit
Oncopeltus fasciatus
milkweed bug - (species)
Lygaeus kalmii
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Labidomera clivicollis
(species) D
Intergeneric or Higher
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
1 Additional References
GP00000710
Atp1a1
Q8VDN2
Physiology
2 mutations
Insecta
true insects - (class)
Labidomera clivicollis
(species) D
Na/K-ATPase alpha-subunit
Labidomera clivicollis
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Liriomyza asclepiadis
(species) D
Interspecific
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
GP00000711
Atp1a1
Q8VDN2
Physiology
N122H
Insecta
true insects - (class)
Liriomyza asclepiadis
(species) D
Na/K-ATPase alpha-subunit
Liriomyza asclepiadis
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Aphis nerii
oleander aphid - (species)
Interspecific
Candidate Gene
Zhen Y; Aardema ML; Medina EM ; et al. (2012)
Parallel molecular evolution in an herbivore community.
GP00000712
K+ ATPase alpha subunit
R4ZHW8
Physiology
2 mutations
Insecta
true insects - (class)
Aphis nerii
oleander aphid - (species)
Na/K-ATPase alpha-subunit
Aphis nerii
oleander aphid - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Cycnia tenera
delicate cyncia - (species)
Lerina incarnata
(species)
Interspecific
Candidate Gene
Zhen Y; Aardema ML; Medina EM ; et al. (2012)
Parallel molecular evolution in an herbivore community.
1 Additional References
GP00000713
Atp1a1
Q8VDN2
Physiology
Q111L
Lepidoptera
butterflies and moths - (order)
Cycnia tenera
delicate cyncia - (species)
Lerina incarnata
(species)
Na/K-ATPase alpha-subunit
Cycnia tenera
delicate cyncia - (species)
Lerina incarnata
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Murinae
(subfamily) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000714
Atp1a1
Q8VDN2
Physiology
2 mutations
Rodentia
rodent - (order)
Murinae
(subfamily) D
Na/K-ATPase alpha-subunit
Murinae
(subfamily)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Varanus varius
lace monitor - (species) D
Varanus tristis
(species) D
Varanus scalaris
(species) D
Interspecific
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000715
Atp1a1
Q8VDN2
Physiology
2 mutations
Varanus salvator
water monitor - (species)
Varanus rudicollis
roughneck monitor - (species)
Varanus dumerilii
Dumeril monitor - (species)
Varanus varius
lace monitor - (species) D
Varanus tristis
(species) D
Varanus scalaris
(species) D
Na/K-ATPase alpha-subunit
Varanus varius
lace monitor - (species)
Varanus tristis
(species)
Varanus scalaris
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Bitis arietans
puff adder - (species) D
Bitis nasicornis
rhinoceros viper - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00000716
Atp1a1
Q8VDN2
Physiology
2 mutations
Vipera berus
adder - (species)
Bitis arietans
puff adder - (species) D
Bitis nasicornis
rhinoceros viper - (species) D
Na/K-ATPase alpha-subunit
Bitis arietans
puff adder - (species)
Bitis nasicornis
rhinoceros viper - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
Unknown
Hydra vulgaris
(species) D
Intergeneric or Higher
Candidate Gene
Canfield VA; Xu KY; D'Aquila T ; et al. (1992)
Molecular cloning and characterization of Na,K-ATPase from Hydra vulgaris: implications for enzyme e[...]
GP00001738
Atp1a1
Q8VDN2
Physiology
Eumetazoa
(no rank)
Hydra vulgaris
(species) D
Na/K-ATPase alpha-subunit
Hydra vulgaris
(species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Rattus norvegicus
Norway rat - (species) D
Mus musculus
house mouse - (species) D
Mesocricetus auratus
golden hamster - (species) D
Peromyscus maniculatus
North American deer mouse - (species) D
Nannospalax galili
Upper Galilee mountains blind mole rat - (species) D
Intergeneric or Higher
Candidate Gene
Shull GE; Greeb J; Lingrel JB (1986)
Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain.
1 Additional References
GP00001739
Atp1a1
Q8VDN2
Physiology
2 mutations
Jaculus jaculus
lesser Egyptian jerboa - (species)
Spermophilus
old world ground squirrels - (genus)
Rattus norvegicus
Norway rat - (species) D
Mus musculus
house mouse - (species) D
Mesocricetus auratus
golden hamster - (species) D
Peromyscus maniculatus
North American deer mouse - (species) D
Nannospalax galili
Upper Galilee mountains blind mole rat - (species) D
Na/K-ATPase alpha-subunit
Rattus norvegicus
Norway rat - (species)
Mus musculus
house mouse - (species)
Mesocricetus auratus
golden hamster - (species)
Peromyscus maniculatus
North American deer mouse - (species)
Nannospalax galili
Upper Galilee mountains blind mole rat - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Oncopeltus fasciatus
milkweed bug - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
1 Additional References
GP00001740
Atp1a1
Q8VDN2
Physiology
Q111T
Lygaeus kalmii
(species)
Oncopeltus fasciatus
milkweed bug - (species) D
Na/K-ATPase alpha-subunit
Oncopeltus fasciatus
milkweed bug - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Liriomyza
(genus) D
Interspecific
Candidate Gene
Dobler S; Dalla S; Wagschal V ; et al. (2012)
Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in t[...]
1 Additional References
GP00001741
Atp1a1
Q8VDN2
Physiology
Q111L
Phytomyzinae
(subfamily)
Liriomyza
(genus) D
Na/K-ATPase alpha-subunit
Liriomyza
(genus)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
Coding,
SNP
Saucrobotys futilalis
dogbane pyralid moth - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
GP00001742
Atp1a1
Q8VDN2
Physiology
Q111L
Holometabola
(cohort)
Saucrobotys futilalis
dogbane pyralid moth - (species) D
Na/K-ATPase alpha-subunit
Saucrobotys futilalis
dogbane pyralid moth - (species)
Published - Accepted by Curator